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Patients were randomized to one of two doses of varenicline, adjusted by weight to provide plasma levels in the efficacious range (based on adult studies) and placebo

Pregnant and breastfeeding women, night-shift workers, patients with any addiction other than smoking, patients with any psychiatric disease other than a history of anxiety and depression, patients with a diagnosis of obstructive sleep apnea syndrome (OSAS) and body mass index 30 kg/m 2 were excluded

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202234 Hedges LV, Olkin I (1985) Statistical methods for meta-analysis

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